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Quality Control for the Studbook or pedigree

Source: R/qcStudbook.R
qcStudbook.Rd

Main pedigree curation function that performs basic quality control on pedigree information

Usage

qcStudbook(sb, minParentAge = 2, reportChanges = FALSE, reportErrors = FALSE)

Arguments

sb

A dataframe containing a table of pedigree and demographic information.

The function recognizes the following columns (optional columns will be used if present, but are not required):

  • {id} {— Character vector with Unique identifier for all individuals}

  • {sire} {— Character vector with unique identifier for the father of the current id}

  • {dam} {— Character vector with unique identifier for the mother of the current id}

  • {sex} {— Factor {levels: "M", "F", "U"} Sex specifier for an individual}

  • {birth} {— Date or NA (optional) with the individual's birth date}

  • {departure} {— Date or NA (optional) an individual was sold or shipped from the colony}

  • {death} {— date or NA (optional) Date of death, if applicable}

  • {status} {— Factor {levels: ALIVE, DEAD, SHIPPED} (optional) Status of an individual}

  • {origin} {— Character or NA (optional) Facility an individual originated from, if other than ONPRC}

  • {ancestry} {— Character or NA (optional) Geographic population to which the individual belongs}

  • {spf} {— Character or NA (optional) Specific pathogen-free status of an individual}

  • {vasxOvx} {— Character or NA (optional) Indicator of the vasectomy/ovariectomy status of an animal; NA if animal is intact, assume all other values indicate surgical alteration}

  • {condition} {— Character or NA (optional) Indicator of the restricted status of an animal. "Nonrestricted" animals are generally assumed to be naive.}

minParentAge

numeric values to set the minimum age in years for an animal to have an offspring. Defaults to 2 years. The check is not performed for animals with missing birth dates.

reportChanges

logical value that if TRUE, the errorLst contains the list of changes made to the column names. Default is FALSE.

reportErrors

logical value if TRUE will scan the entire file and report back changes made to input and errors in a list of list where each sublist is a type of change or error found. Changes will include column names, case of categorical values (male, female, unknown), etc. Errors will include missing columns, invalid date rows, male dams, female sires, and records with one or more parents below minimum age of parents.

The following changes are made to the cols.

  • {Column cols are converted to all lower case}

  • {Periods (".") within column cols are collapsed to no space ""}

  • {egoid is converted to id}

  • {sireid is convert to sire}

  • {damid is converted to dam}

If the dataframe (sb does not contain the five required columns (id, sire, dam, sex), and birth the function throws an error by calling stop().

If the id field has the string UNKNOWN (any case) or both the fields sire or dam have NA or UNKNOWN (any case), the record is removed. If either of the fields sire or dam have the string UNKNOWN (any case), they are replaced with a unique identifier with the form Unnnn, where nnnn represents one of a series of sequential integers representing the number of missing sires and dams right justified in a pattern of 0000. See addUIds function.

The function addParents is used to add records for parents missing their own record in the pedigree.

The function convertSexCodes is used with ignoreHerm == TRUE to convert sex codes according to the following factors of standardized codes:

  • {F} {– replacing "FEMALE" or "2"}

  • {M} {– replacing "MALE" or "1"}

  • {H} {– replacing "HERMAPHRODITE" or "4", if ignore.herm == FALSE}

  • {U} {– replacing "HERMAPHRODITE" or "4", if ignore.herm == TRUE}

  • {U} {– replacing "UNKNOWN" or "3"}

The function correctParentSex is used to ensure no parent is both a sire and a dam. If this error is detected, the function throws an error and halts the program.

The function convertStatusCodes converts status indicators to the following factors of standardized codes. Case of the original status value is ignored.

  • {"ALIVE"} {— replacing "alive", "A" and "1"}

  • {"DECEASED"} {— replacing "deceased", "DEAD", "D", "2"}

  • {"SHIPPED"} {— replacing "shipped", "sold", "sale", "s", "3"}

  • {"UNKNOWN"} {— replacing is.na(status)}

  • {"UNKNOWN"} {— replacing "unknown", "U", "4"}

The function convertAncestry coverts ancestry indicators using regular expressions such that the following conversions are made from character strings that match selected substrings to the following factors.

  • {"INDIAN"} {— replacing "ind" and not "chin"}

  • {"CHINESE"} {— replacing "chin" and not "ind"}

  • {"HYBRID"} {— replacing "hyb" or "chin" and "ind"}

  • {"JAPANESE"} {— replacing "jap"}

  • {"UNKNOWN"} {— replacing NA}

  • {"OTHER"} {— replacing not matching any of the above}

The function convertDate converts character representations of dates in the columns birth, death, departure, and exit to dates using the as.Date function.

The function setExit uses heuristics and the columns death and departure to set exit if it is not already defined.

The function calcAge uses the birth and the exit columns to define the age column. The numerical values is rounded to the nearest 0.1 of a year. If exit is not defined, the current system date (Sys.Date()) is used.

The function findGeneration is used to define the generation number for each animal in the pedigree.

The function removeDuplicates checks for any duplicated records and removes the duplicates. I also throws an error and stops the program if an ID appears in more than one record where one or more of the other columns have a difference.

Columns that cannot be used subsequently are removed and the rows are ordered by generation number and then ID.

Finally the columns id sire, and dam are coerce to character.

Value

A data.frame with standardized and quality controlled pedigree information.

Examples

examplePedigree <- nprcgenekeepr::examplePedigree
ped <- qcStudbook(examplePedigree,
  minParentAge = 2.0, reportChanges = FALSE,
  reportErrors = FALSE
)
names(ped)
#>  [1] "id"           "sire"         "dam"          "sex"          "gen"         
#>  [6] "birth"        "exit"         "age"          "ancestry"     "origin"      
#> [11] "status"       "recordStatus"